The Regulatory T-cell Transcription Factor Foxp3 Protects against Crescentic Glomerulonephritis
نویسندگان
چکیده
منابع مشابه
Latent TGF- 1 Protects Against Crescentic Glomerulonephritis
Despite the critical role that TGFplays in renal fibrosis, transgenic mice that overexpress human latent TGF1 in the skin exhibit normal renal histology and function even though circulating levels of latent TGF1 are an order of magnitude higher than wild-type animals. In fact, latent TGF1 seems to protect against renal inflammation in a model of ureteral obstruction. It is unknown, however, whe...
متن کاملT cells in crescentic glomerulonephritis.
Crescent formation in glomerulonephritis (GN) is a manifestation of severe glomerular injury that usually results in a poor clinical outcome. In humans, crescentic GN is frequently associated with evidence of either systemic or organ-specific autoimmunity. T cells play a major role in initiation of adaptive immune responses that lead to crescentic injury. In experimental models of crescentic GN...
متن کاملControl of regulatory T cell development by the transcription factor Foxp3.
Regulatory T cells engage in the maintenance of immunological self-tolerance by actively suppressing self-reactive lymphocytes. Little is known, however, about the molecular mechanism of their development. Here we show that Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in natural...
متن کاملIκB(NS) protein mediates regulatory T cell development via induction of the Foxp3 transcription factor.
Forkhead box P3 positive (Foxp3(+)) regulatory T (Treg) cells suppress immune responses and regulate peripheral tolerance. Here we show that the atypical inhibitor of NFκB (IκB) IκB(NS) drives Foxp3 expression via association with the promoter and the conserved noncoding sequence 3 (CNS3) of the Foxp3 locus. Consequently, IκB(NS) deficiency leads to a substantial reduction of Foxp3(+) Treg cell...
متن کاملAdoptive regulatory T-cell therapy protects against cerebral ischemia.
OBJECTIVE Recent evidence suggests that functional deficiency in regulatory T cells (Tregs), an innate immunomodulator, exacerbates brain damage after cerebral ischemia. We therefore evaluated the effect of Treg transfer in rodent models of ischemic stroke and further investigated the mechanism underlying Treg-afforded neuroprotection. METHODS We examined the therapeutic potential of Tregs an...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-01515-8